The power of genomics, metabolomics, and other omics for target identification and validation

David M. Pereira, João C. Fernandes

Resultado de pesquisarevisão de pares

Resumo

The application of omics ranges from drug discovery and development to diagnosis of diseases, by following their progression, improving efficacy and safety of treatments, optimizing patient selection and identification of responders/nonresponders, adapting dose regimens of drugs, and helping to decide which therapy is most appropriate. For obvious reasons an integrated approach should be followed as a strategy to avoid misinterpretations of data. For example, changes found at the gene level may not necessarily translate into altered levels of proteins. Here, we address the basis of genomics and metabolomics, highlighting the most used techniques in each case and its current and future applications in human health and disease.

Idioma originalEnglish
Título da publicação do anfitriãoPrinciples of translational science in medicine
Subtítulo da publicação do anfitriãofrom bench to bedside, third edition
EditoresMartin Wehling
EditoraElsevier
Páginas33-48
Número de páginas16
Edição3
ISBN (eletrónico)9780128204931
ISBN (impresso)9780323999625
DOIs
Estado da publicaçãoPublicado - 1 jan 2021

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