Toward a universal unit for quantification of antibiotic resistance genes in environmental samples

Xiaole Yin, Xi Chen, Xiao Tao Jiang, Ying Yang, Bing Li, Marcus Ho Hin Shum, Tommy T.Y. Lam, Gabriel M. Leung, Joan Rose, Concepcion Sanchez-Cid, Timothy M. Vogel, Fiona Walsh, Thomas U. Berendonk, Janet Midega, Chibuzor Uchea, Dominic Frigon, Gerard D. Wright, Carlos Bezuidenhout, Renata C. Picão, Shaikh Z. AhammadPer Halkjær Nielsen, Philip Hugenholtz, Nicholas J. Ashbolt, Gianluca Corno, Despo Fatta-Kassinos, Helmut Bürgmann, Heike Schmitt, Chang Jun Cha, Amy Pruden, Kornelia Smalla, Eddie Cytryn, Yu Zhang, Min Yang, Yong Guan Zhu, Arnaud Dechesne, Barth F. Smets, David W. Graham, Michael R. Gillings, William H. Gaze, Célia M. Manaia, Mark C.M. Van Loosdrecht, Pedro J.J. Alvarez, Martin J. Blaser, James M. Tiedje, Edward Topp, Tong Zhang*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

24 Citações (Scopus)

Resumo

Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in environmental sectors to complement the surveys in human and animal sectors under the "One-Health"framework. However, there are substantial challenges in comparing and synthesizing the results of multiple studies that employ different test methods and approaches in bioinformatic analysis. In this article, we consider the commonly used quantification units (ARG copy per cell, ARG copy per genome, ARG density, ARG copy per 16S rRNA gene, RPKM, coverage, PPM, etc.) for profiling ARGs and suggest a universal unit (ARG copy per cell) for reporting such biological measurements of samples and improving the comparability of different surveillance efforts.
Idioma originalEnglish
Páginas (de-até)9713-9721
Número de páginas9
RevistaEnvironmental Science and Technology
Volume57
Número de emissão26
DOIs
Estado da publicaçãoPublicado - 4 jul. 2023

Impressão digital

Mergulhe nos tópicos de investigação de “Toward a universal unit for quantification of antibiotic resistance genes in environmental samples“. Em conjunto formam uma impressão digital única.

Citação