Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots

Ana Sofia Sousa; André Mayer; Celso Reis; Maria Manuela Pintado; Ezequiel R. Coscueta

Resumo

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

Idioma original	English
Páginas	1-3
Número de páginas	3
Estado da publicação	Publicado - jul. 2025
Evento	CRS 2025 Annual Meeting & Exposition: Next-Generation Delivery Innovations - Philadelphia, PA Duração: 14 jul. 2025 → 18 jul. 2025 https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition

Conferência

Conferência	CRS 2025 Annual Meeting & Exposition
Título abreviado	CRS 2025
País/Território	United States
Cidade	Philadelphia, PA
Período	14/07/25 → 18/07/25
Endereço da Internet	https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition

ODS da ONU

Este resultado contribui para o(s) seguinte(s) Objetivo(s) de Desenvolvimento Sustentável

ODS 3 Boa saúde e bem-estar

Acesso ao documento

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Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots
Sousa, A. S. D. S. (Speaker), Mayer, A. D. N. D. S. (Speaker), Reis, C. (Speaker), Pintado, M. M. (Speaker) & Coscueta, E. (Speaker)
17 jul. 2025
Atividade

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029
Pintado, M. M. (PI)
1/01/25 → 31/12/29
Projeto
microHEROS: Microbots for gastrointestinal health: Targeting Helicobacter pylori infection and ROS imbalance
Coscueta, E. (PI)
1/11/24 → 31/10/30
Projeto
gBiOT: Nutraceutical biopolymeric-biocatalytic microbot against gut inflammatory disorders
Coscueta, E. (PI), Pintado, M. M. (CoPI), Machado, M. (Investigador), Coelho, M. (Investigador), Rodrigues, P. M. (Investigador), Sousa, A. S. D. S. (Investigador), Sousa, C. (Investigador), Magalhães, A. (Investigador) & Santos Matos, R. D. (Investigador)
Fundação para a Ciência e a Tecnologia
1/03/23 → 28/02/27
Projeto

CBQF researchers as invited speakers at the world’s leading conference on drug delivery technologies
Coscueta, E. & Sousa, A. S. D. S.
28/07/25
1 item de Cobertura de meios de comunicação
Imprensa/meios de comunicação

Desenvolvimento de um nanobot com propulsão biocatalítica e neutralizante das espécies reativas de oxigénio co cólon inflamado
Mayer, A. D. N. D. S. (Aluno), Coscueta, E. R. (Supervisor) & Pintado, M. M. E. (Co-Orientador), 17 dez. 2024
Tese do aluno: Dissertação de mestrado

Citação

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title = "Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots",

abstract = "Inflammatory bowel disease (IBD), including Crohn{\textquoteright}s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract. ",

author = "Sousa, \{Ana Sofia\} and Andr{\'e} Mayer and Celso Reis and Pintado, \{Maria Manuela\} and Coscueta, \{Ezequiel R.\}",

year = "2025",

month = jul,

language = "English",

pages = "1--3",

note = "CRS 2025 Annual Meeting \& Exposition : Next-Generation Delivery Innovations, CRS 2025 ; Conference date: 14-07-2025 Through 18-07-2025",

url = "https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition",

}

TY - CONF

T1 - Transforming healthcare

T2 - CRS 2025 Annual Meeting & Exposition

AU - Sousa, Ana Sofia

AU - Mayer, André

AU - Reis, Celso

AU - Pintado, Maria Manuela

AU - Coscueta, Ezequiel R.

PY - 2025/7

Y1 - 2025/7

N2 - Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

AB - Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

M3 - Abstract

SP - 1

EP - 3

Y2 - 14 July 2025 through 18 July 2025

ER -

Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots

Resumo

Conferência

ODS da ONU

Acesso ao documento

???embargo-document???

Impressão digital

Atividades

Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots

Projetos

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029

microHEROS: Microbots for gastrointestinal health: Targeting Helicobacter pylori infection and ROS imbalance

gBiOT: Nutraceutical biopolymeric-biocatalytic microbot against gut inflammatory disorders

Imprensa/meios de comunicação

CBQF researchers as invited speakers at the world’s leading conference on drug delivery technologies

Teses do aluno

Desenvolvimento de um nanobot com propulsão biocatalítica e neutralizante das espécies reativas de oxigénio co cólon inflamado

Citação