Ulcerative colitis as a progressive disease: The forgotten evidence

Joana Torres, Vincent Billioud, David B. Sachar, Laurent Peyrin-Biroulet, Jean Fred́éric Colombel*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

209 Citações (Scopus)

Resumo

In the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long-term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined.

Idioma originalEnglish
Páginas (de-até)1356-1363
Número de páginas8
RevistaInflammatory Bowel Diseases
Volume18
Número de emissão7
DOIs
Estado da publicaçãoPublicado - jul. 2012

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